Thomas married Patience Brewster on 5 Aug 1624 in , Plymouth, Massachusetts, USA. Patience (daughter of Elder William Brewster and Mary Love Wentworth) was born in 1605 in Scrooby, Nottinghamshire, England; died on 12 Dec 1634 in Plymouth, Plymouth, Massachusetts, United States. [Group Sheet]

1. Elizabeth Prence was born in 1624; died on 28 Mar 1673 in Duxbury, Plymouth, Massachusetts, USA.
2. Thomas Prence was born on 22 May 1627 in Plymouth, Plymouth Co, Massachusetts, USA; died on 13 Mar 1672 in England.
3. Rebecca Prence was born on 1 Jun 1627 in Plymouth, Plymouth Co, Massachusetts, USA; died on 18 Jul 1651 in Sandwich, Barnstable Co, Massachusetts, USA.
4. Mercy Prence was born in 1631 in Easthamm Mass; died on 28 Sep 1711 in Easthamm Mass.
5. Hannah Prence was born about 1634 in Plymouth, Massachusetts (Plymouth); died on 25 Nov 1698 in Eastham, Massachusetts (Barnstable).